Fibersol-2 induces apoptosis of Apc-deficient colorectal Cancer (SW480) cells and decreases polyp formation in Apc MIN mice

The consumption of dietary fibers has been implicated with a lowered risk of human colorectal cancer. Proposed mechanisms involve alterations in the stool consistency, transit time, and formation of short-chain fatty acid by dietary fiber fermentation, and the reorganization of gut microbiota. Here...

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Bibliographic Details
Published in:Cancer biology & therapy 2016-06, Vol.17 (6), p.657-663
Main Authors: Sancho, Sara Cuesta, Olson, Susan Losee, Young So, Eui, Shimomura, Kazuhiro, Ouchi, Toru, Preuss, Fabian
Format: Article
Language:English
Subjects:
Animals
Apc
Apoptosis
cancer
Cell Proliferation
Colorectal Neoplasms - pathology
Colorectal Neoplasms - prevention & control
Dietary Fiber - administration & dosage
Dietary Fiber - therapeutic use
Disease Models, Animal
Female
fibersol
Humans
Male
maltodextrin
Mice
Mice, Inbred C57BL
MIN
Polyps - metabolism
Reactive Oxygen Species
Research Paper
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Summary:The consumption of dietary fibers has been implicated with a lowered risk of human colorectal cancer. Proposed mechanisms involve alterations in the stool consistency, transit time, and formation of short-chain fatty acid by dietary fiber fermentation, and the reorganization of gut microbiota. Here we show that Fibersol-2, a digest-resistant maltodextrin, not only inhibits proliferation of colorectal SW480 cancer cell lines by increasing reactive oxygen species (ROS), but decreases the numbers of the adenoma count in Multiple Intestinal Neoplasia (MIN) mice carrying a mutation in the Adenomatous Polyposis Coli gene by 84 d of age. These observations provide direct evidence that Fibersol-2 intrinsically contains anti-cancer activity, independent of the intestinal metabolism and any potential interactions with the microbiota.
ISSN:1538-4047
1555-8576
DOI:10.1080/15384047.2016.1177685