Size and Surface Charge of Engineered Poly(amidoamine) Dendrimers Modulate Tumor Accumulation and Penetration: A Model Study Using Multicellular Tumor Spheroids

An enormous effort has been put into designing nanoparticles (NPs) with controlled biodistributions, prolonged plasma circulation times, and/or enhanced tissue targeting. However, little is known about how to design NPs with precise distributions in the target tissues. In particular, understanding N...

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Bibliographic Details
Published in:Molecular pharmaceutics 2016-07, Vol.13 (7), p.2155-2163
Main Authors: Bugno, Jason, Hsu, Hao-Jui, Pearson, Ryan M, Noh, Hyeran, Hong, Seungpyo
Format: Article
Language:English
Subjects:
Cations - chemistry
Cell Line, Tumor
Dendrimers - administration & dosage
Dendrimers - chemistry
Drug Carriers - chemistry
Drug Delivery Systems - methods
Humans
KB Cells
MCF-7 Cells
Neoplasms - drug therapy
Particle Size
Polyamines - administration & dosage
Polyamines - chemistry
Spheroids, Cellular - chemistry
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Summary:An enormous effort has been put into designing nanoparticles (NPs) with controlled biodistributions, prolonged plasma circulation times, and/or enhanced tissue targeting. However, little is known about how to design NPs with precise distributions in the target tissues. In particular, understanding NP tumor penetration and accumulation characteristics is crucial to maximizing the therapeutic potential of drug molecules carried by the NPs. In this study, we employed poly­(amidoamine) (PAMAM) dendrimers, given their well-controlled size (
ISSN:1543-8384
1543-8392
DOI:10.1021/acs.molpharmaceut.5b00946