Chemical structures of constituents from the whole plant of Bacopa monniera

Two new dammarane-type triterpene oligoglycosides, bacomosaponins A and B, and three new phenylethanoid glycosides, bacomosides A, B 1 , and B 2 , were isolated from the whole plant of Bacopa monniera Wettst. The chemical structures of the new constituents were characterized on the basis of chemical...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural medicines 2016-07, Vol.70 (3), p.404-411
Main Authors: Ohta, Tomoe, Nakamura, Seikou, Nakashima, Souichi, Oda, Yoshimi, Matsumoto, Takahiro, Fukaya, Masashi, Yano, Mamiko, Yoshikawa, Masayuki, Matsuda, Hisashi
Format: Article
Language:English
Subjects:
Bacopa - chemistry
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Dammaranes
Medicinal Chemistry
Molecular Structure
Original Paper
Pharmacology/Toxicology
Pharmacy
Plant Extracts - chemistry
Plant Sciences
Triterpenes - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new dammarane-type triterpene oligoglycosides, bacomosaponins A and B, and three new phenylethanoid glycosides, bacomosides A, B 1 , and B 2 , were isolated from the whole plant of Bacopa monniera Wettst. The chemical structures of the new constituents were characterized on the basis of chemical and physicochemical evidence. In the present study, bacomosaponins A and B with acyl groups were obtained from the whole plant of B. monniera . This is the first report of acylated dammarane-type triterpene oligoglycosides isolated from B. monniera . In addition, dammarane-type triterpene saponins significantly inhibited the aggregation of 42-mer amyloid β-protein.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-016-0986-0