Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)

Highlights • A correlation between PD-L1 mRNA expression and H-score was strong in cell lines. • PD-L1 was expressed in 22% of adenocarcinomas and 60% of squamous cell cancers. • PD-L1 expression was associated with high proliferation and EMT in adenocarcinoma. • PD-L1 expression was a significant p...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-08, Vol.98, p.69-75
Main Authors: Shimoji, Masaki, Shimizu, Shigeki, Sato, Katsuaki, Suda, Kenichi, Kobayashi, Yoshihisa, Tomizawa, Kenji, Takemoto, Toshiki, Mitsudomi, Tetsuya
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - diagnosis
Adenocarcinoma - genetics
Adenocarcinoma of Lung
Aged
Aged, 80 and over
B7-H1 Antigen - genetics
B7-H1 Antigen - metabolism
Biomarkers, Tumor
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - genetics
EMT
Epithelial-Mesenchymal Transition - genetics
Female
Gene Expression
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - therapy
Male
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
PD-L1
Prognosis
Prognostic factor
Proportional Hazards Models
Pulmonary/Respiratory
RNA, Messenger - genetics
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Summary:Highlights • A correlation between PD-L1 mRNA expression and H-score was strong in cell lines. • PD-L1 was expressed in 22% of adenocarcinomas and 60% of squamous cell cancers. • PD-L1 expression was associated with high proliferation and EMT in adenocarcinoma. • PD-L1 expression was a significant poor prognostic factor in lung adenocarcinoma.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.04.021