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Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)

Highlights • A correlation between PD-L1 mRNA expression and H-score was strong in cell lines. • PD-L1 was expressed in 22% of adenocarcinomas and 60% of squamous cell cancers. • PD-L1 expression was associated with high proliferation and EMT in adenocarcinoma. • PD-L1 expression was a significant p...

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Published in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-08, Vol.98, p.69-75
Main Authors:	Shimoji, Masaki, Shimizu, Shigeki, Sato, Katsuaki, Suda, Kenichi, Kobayashi, Yoshihisa, Tomizawa, Kenji, Takemoto, Toshiki, Mitsudomi, Tetsuya
Format:	Article
Language:	English
Subjects:	Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenocarcinoma of Lung Aged Aged, 80 and over B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biomarkers, Tumor Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics EMT Epithelial-Mesenchymal Transition - genetics Female Gene Expression Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Kaplan-Meier Estimate Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - therapy Male Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Staging PD-L1 Prognosis Prognostic factor Proportional Hazards Models Pulmonary/Respiratory RNA, Messenger - genetics
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creator	Shimoji, Masaki Shimizu, Shigeki Sato, Katsuaki Suda, Kenichi Kobayashi, Yoshihisa Tomizawa, Kenji Takemoto, Toshiki Mitsudomi, Tetsuya
description	Highlights • A correlation between PD-L1 mRNA expression and H-score was strong in cell lines. • PD-L1 was expressed in 22% of adenocarcinomas and 60% of squamous cell cancers. • PD-L1 expression was associated with high proliferation and EMT in adenocarcinoma. • PD-L1 expression was a significant poor prognostic factor in lung adenocarcinoma.
doi_str_mv	10.1016/j.lungcan.2016.04.021
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subjects	Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenocarcinoma of Lung Aged Aged, 80 and over B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biomarkers, Tumor Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics EMT Epithelial-Mesenchymal Transition - genetics Female Gene Expression Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Kaplan-Meier Estimate Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - therapy Male Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Staging PD-L1 Prognosis Prognostic factor Proportional Hazards Models Pulmonary/Respiratory RNA, Messenger - genetics
title	Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)
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