Quantitation of Metabolites of the Nerve Agents Sarin, Soman, Cyclohexylsarin, VX, and Russian VX in Human Urine Using Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry

Organophosphorus nerve agents are among the most toxic organic compounds known and continue to be a threat for both military and terrorist use. We have developed an isotope-dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method for quantitating the urinary metabolites of the organop...

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Bibliographic Details
Published in:Journal of analytical toxicology 2004-08, Vol.28 (4), p.372-378
Main Authors: Barr, J R, Driskell, W J, Aston, L S, Martinez, R A
Format: Article
Language:English
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Summary:Organophosphorus nerve agents are among the most toxic organic compounds known and continue to be a threat for both military and terrorist use. We have developed an isotope-dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method for quantitating the urinary metabolites of the organophosphorus nerve agents sarin (GB), soman (GD), VX, Russian VX (RVX), and cyclohexylsarin (GF). Urine samples were acidified, extracted into ether-acetonitrile, derivatized by methylation with diazomethane, and analyzed by GC-MS-MS. The limits of detection were less than 1 mu g/L for all analytes.
ISSN:0146-4760