DNA analysis of an early modern human from Tianyuan Cave, China

Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatom...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (6), p.2223-2227
Main Authors: Fu, Qiaomei, Meyer, Matthias, Gao, Xing, Stenzel, Udo, Burbano, Hernán A., Kelso, Janet, Pääbo, Svante
Format: Article
Language:English
Subjects:
American Indians
Animals
Asian Continental Ancestry Group - genetics
Asian Continental Ancestry Group - history
Asians
Base Sequence
Biological Sciences
Caves
China
Chromosomes
Chromosomes, Human, Pair 21 - genetics
DNA
DNA probes
DNA, Mitochondrial - genetics
DNA, Mitochondrial - history
DNA, Mitochondrial - isolation & purification
Eurasia
Europeans
Fossils
Gene Library
genetic relationships
Genetics, Population
Genomes
History, Ancient
Hominidae - genetics
Hominids
Human genetics
Humans
hybridization
Libraries
Mitochondrial DNA
mitochondrial genome
Molecular Sequence Data
Morphology
nuclear genome
Nucleotide sequences
Phylogeny
Phylogeography
Polymorphism
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Sequencing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (∼30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1221359110