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Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats
Objective To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats. Methods A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg −1 ), middle (30 mg kg −1 ), and high-dose...
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| Published in: | Irish journal of medical science 2016-08, Vol.185 (3), p.581-587 |
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| container_title | Irish journal of medical science |
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| creator | Zhao, S. Niu, F. Xu, C.-Y. Liu, Y. Ye, L. Bi, G.-B. Chen, L. Tian, G. Nie, T.-H. |
| description | Objective
To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats.
Methods
A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg
−1
), middle (30 mg kg
−1
), and high-dose diosgenin (90 mg kg
−1
)-treated groups. The osteoporosis rats model was induced by retinoic acid. The BMD and physical parameters of femoral including length, wet weight, and dry weight in each group were measured. The hematoxylin–eosin staining was used for bone histomorphology analysis. Besides, the bone calcium (Ca) and phosphorus (P) contents were measured. In order to detect the biochemical index in different treatment groups, the serum tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), estradiol, and osteocalcin were compared among different groups.
Results
The osteoporosis rat model was successfully induced by retinoic acid. Compared with the model group, the lessening of femoral length and weight and the loss of BMD were significantly improved in diosgenin groups. Both contents of Ca and P were much more increased when induced by retinoic acid (
p
|
| doi_str_mv | 10.1007/s11845-015-1309-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1804854577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1804854577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-56d1b08d64abf05aafc0a25adaeaac604fdb93a974f214999760af3b1f1a891d3</originalsourceid><addsrcrecordid>eNp9kLtOxDAQRS0EguXxATQoJY1hxnacuES8ERIN1JYTO8ho1148CRJ_T9ACJdUUc-7VzGHsGOEMAZpzQmxVzQFrjhIMF1tsga2WXEktttkCQCBHoes9tk_0BiCN1GqX7QkNrREGFuzhKmZ6DSmmal3CR0gjVV1OoVpmoiqnqoQxphz7yvXR85j81AdfZRpDXueSKVI1Z4sb6ZDtDG5J4ehnHrCXm-vnyzv--HR7f3nxyHup1Mhr7bGD1mvlugFq54YenKidd8G5XoMafGekM40aBCpjTKPBDbLDAV1r0MsDdrrpXZf8PgUa7SpSH5ZLl0KeyGILqq1V3TQzihu0ny-lEga7LnHlyqdFsN8K7UahnRXab4VWzJmTn_qpWwX_l_h1NgNiA9C8Sq-h2Lc8lTS__E_rF4yafO4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1804854577</pqid></control><display><type>article</type><title>Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats</title><source>Springer Link</source><creator>Zhao, S. ; Niu, F. ; Xu, C.-Y. ; Liu, Y. ; Ye, L. ; Bi, G.-B. ; Chen, L. ; Tian, G. ; Nie, T.-H.</creator><creatorcontrib>Zhao, S. ; Niu, F. ; Xu, C.-Y. ; Liu, Y. ; Ye, L. ; Bi, G.-B. ; Chen, L. ; Tian, G. ; Nie, T.-H.</creatorcontrib><description>Objective
To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats.
Methods
A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg
−1
), middle (30 mg kg
−1
), and high-dose diosgenin (90 mg kg
−1
)-treated groups. The osteoporosis rats model was induced by retinoic acid. The BMD and physical parameters of femoral including length, wet weight, and dry weight in each group were measured. The hematoxylin–eosin staining was used for bone histomorphology analysis. Besides, the bone calcium (Ca) and phosphorus (P) contents were measured. In order to detect the biochemical index in different treatment groups, the serum tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), estradiol, and osteocalcin were compared among different groups.
Results
The osteoporosis rat model was successfully induced by retinoic acid. Compared with the model group, the lessening of femoral length and weight and the loss of BMD were significantly improved in diosgenin groups. Both contents of Ca and P were much more increased when induced by retinoic acid (
p
< 0.05). The estradiol and osteocalcin levels in the middle and high-dose treatment groups were significantly higher than that of the model group, while the ALP and TRAP levels were much lower than the model group (
p
< 0.05).
Conclusion
Diosgenin can prevent the loss of bone in experimental rats. The mechanism may be that it improves the level of estrogenic hormone of estradiol and inhibits the high bone turnover.</description><identifier>ISSN: 0021-1265</identifier><identifier>EISSN: 1863-4362</identifier><identifier>DOI: 10.1007/s11845-015-1309-2</identifier><identifier>PMID: 26089290</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Animals ; Bone Density - drug effects ; Diosgenin - administration & dosage ; Diosgenin - therapeutic use ; Disease Models, Animal ; Family Medicine ; Female ; General Practice ; Internal Medicine ; Medicine ; Medicine & Public Health ; Original Article ; Osteoporosis - chemically induced ; Osteoporosis - drug therapy ; Rats ; Rats, Sprague-Dawley ; Tretinoin - adverse effects</subject><ispartof>Irish journal of medical science, 2016-08, Vol.185 (3), p.581-587</ispartof><rights>Royal Academy of Medicine in Ireland 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-56d1b08d64abf05aafc0a25adaeaac604fdb93a974f214999760af3b1f1a891d3</citedby><cites>FETCH-LOGICAL-c344t-56d1b08d64abf05aafc0a25adaeaac604fdb93a974f214999760af3b1f1a891d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26089290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, S.</creatorcontrib><creatorcontrib>Niu, F.</creatorcontrib><creatorcontrib>Xu, C.-Y.</creatorcontrib><creatorcontrib>Liu, Y.</creatorcontrib><creatorcontrib>Ye, L.</creatorcontrib><creatorcontrib>Bi, G.-B.</creatorcontrib><creatorcontrib>Chen, L.</creatorcontrib><creatorcontrib>Tian, G.</creatorcontrib><creatorcontrib>Nie, T.-H.</creatorcontrib><title>Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats</title><title>Irish journal of medical science</title><addtitle>Ir J Med Sci</addtitle><addtitle>Ir J Med Sci</addtitle><description>Objective
To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats.
Methods
A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg
−1
), middle (30 mg kg
−1
), and high-dose diosgenin (90 mg kg
−1
)-treated groups. The osteoporosis rats model was induced by retinoic acid. The BMD and physical parameters of femoral including length, wet weight, and dry weight in each group were measured. The hematoxylin–eosin staining was used for bone histomorphology analysis. Besides, the bone calcium (Ca) and phosphorus (P) contents were measured. In order to detect the biochemical index in different treatment groups, the serum tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), estradiol, and osteocalcin were compared among different groups.
Results
The osteoporosis rat model was successfully induced by retinoic acid. Compared with the model group, the lessening of femoral length and weight and the loss of BMD were significantly improved in diosgenin groups. Both contents of Ca and P were much more increased when induced by retinoic acid (
p
< 0.05). The estradiol and osteocalcin levels in the middle and high-dose treatment groups were significantly higher than that of the model group, while the ALP and TRAP levels were much lower than the model group (
p
< 0.05).
Conclusion
Diosgenin can prevent the loss of bone in experimental rats. The mechanism may be that it improves the level of estrogenic hormone of estradiol and inhibits the high bone turnover.</description><subject>Animals</subject><subject>Bone Density - drug effects</subject><subject>Diosgenin - administration & dosage</subject><subject>Diosgenin - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Family Medicine</subject><subject>Female</subject><subject>General Practice</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Osteoporosis - chemically induced</subject><subject>Osteoporosis - drug therapy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tretinoin - adverse effects</subject><issn>0021-1265</issn><issn>1863-4362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOxDAQRS0EguXxATQoJY1hxnacuES8ERIN1JYTO8ho1148CRJ_T9ACJdUUc-7VzGHsGOEMAZpzQmxVzQFrjhIMF1tsga2WXEktttkCQCBHoes9tk_0BiCN1GqX7QkNrREGFuzhKmZ6DSmmal3CR0gjVV1OoVpmoiqnqoQxphz7yvXR85j81AdfZRpDXueSKVI1Z4sb6ZDtDG5J4ehnHrCXm-vnyzv--HR7f3nxyHup1Mhr7bGD1mvlugFq54YenKidd8G5XoMafGekM40aBCpjTKPBDbLDAV1r0MsDdrrpXZf8PgUa7SpSH5ZLl0KeyGILqq1V3TQzihu0ny-lEga7LnHlyqdFsN8K7UahnRXab4VWzJmTn_qpWwX_l_h1NgNiA9C8Sq-h2Lc8lTS__E_rF4yafO4</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Zhao, S.</creator><creator>Niu, F.</creator><creator>Xu, C.-Y.</creator><creator>Liu, Y.</creator><creator>Ye, L.</creator><creator>Bi, G.-B.</creator><creator>Chen, L.</creator><creator>Tian, G.</creator><creator>Nie, T.-H.</creator><general>Springer London</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats</title><author>Zhao, S. ; Niu, F. ; Xu, C.-Y. ; Liu, Y. ; Ye, L. ; Bi, G.-B. ; Chen, L. ; Tian, G. ; Nie, T.-H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-56d1b08d64abf05aafc0a25adaeaac604fdb93a974f214999760af3b1f1a891d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bone Density - drug effects</topic><topic>Diosgenin - administration & dosage</topic><topic>Diosgenin - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Family Medicine</topic><topic>Female</topic><topic>General Practice</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Osteoporosis - chemically induced</topic><topic>Osteoporosis - drug therapy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tretinoin - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, S.</creatorcontrib><creatorcontrib>Niu, F.</creatorcontrib><creatorcontrib>Xu, C.-Y.</creatorcontrib><creatorcontrib>Liu, Y.</creatorcontrib><creatorcontrib>Ye, L.</creatorcontrib><creatorcontrib>Bi, G.-B.</creatorcontrib><creatorcontrib>Chen, L.</creatorcontrib><creatorcontrib>Tian, G.</creatorcontrib><creatorcontrib>Nie, T.-H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Irish journal of medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, S.</au><au>Niu, F.</au><au>Xu, C.-Y.</au><au>Liu, Y.</au><au>Ye, L.</au><au>Bi, G.-B.</au><au>Chen, L.</au><au>Tian, G.</au><au>Nie, T.-H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats</atitle><jtitle>Irish journal of medical science</jtitle><stitle>Ir J Med Sci</stitle><addtitle>Ir J Med Sci</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>185</volume><issue>3</issue><spage>581</spage><epage>587</epage><pages>581-587</pages><issn>0021-1265</issn><eissn>1863-4362</eissn><abstract>Objective
To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats.
Methods
A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg
−1
), middle (30 mg kg
−1
), and high-dose diosgenin (90 mg kg
−1
)-treated groups. The osteoporosis rats model was induced by retinoic acid. The BMD and physical parameters of femoral including length, wet weight, and dry weight in each group were measured. The hematoxylin–eosin staining was used for bone histomorphology analysis. Besides, the bone calcium (Ca) and phosphorus (P) contents were measured. In order to detect the biochemical index in different treatment groups, the serum tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), estradiol, and osteocalcin were compared among different groups.
Results
The osteoporosis rat model was successfully induced by retinoic acid. Compared with the model group, the lessening of femoral length and weight and the loss of BMD were significantly improved in diosgenin groups. Both contents of Ca and P were much more increased when induced by retinoic acid (
p
< 0.05). The estradiol and osteocalcin levels in the middle and high-dose treatment groups were significantly higher than that of the model group, while the ALP and TRAP levels were much lower than the model group (
p
< 0.05).
Conclusion
Diosgenin can prevent the loss of bone in experimental rats. The mechanism may be that it improves the level of estrogenic hormone of estradiol and inhibits the high bone turnover.</abstract><cop>London</cop><pub>Springer London</pub><pmid>26089290</pmid><doi>10.1007/s11845-015-1309-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Irish journal of medical science, 2016-08, Vol.185 (3), p.581-587 |
| issn | 0021-1265 1863-4362 |
| language | eng |
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| source | Springer Link |
| subjects | Animals Bone Density - drug effects Diosgenin - administration & dosage Diosgenin - therapeutic use Disease Models, Animal Family Medicine Female General Practice Internal Medicine Medicine Medicine & Public Health Original Article Osteoporosis - chemically induced Osteoporosis - drug therapy Rats Rats, Sprague-Dawley Tretinoin - adverse effects |
| title | Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats |
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