Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients

Background and aims In this study, we compared duration for reaching desired Ramsay Sedation Score (RSS) and postoperative recovery according to Modified Aldrete Score (MAS) of propofol and propofol-ketamine combination in a group of colonoscopy patients. Rates of cardiovascular, respiratory, laryng...

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Bibliographic Details
Published in:Irish journal of medical science 2016-08, Vol.185 (3), p.699-704
Main Authors: Baykal Tutal, Z., Gulec, H., Derelı, N., Babayıgıt, M., Kurtay, A., Inceoz, H., Horasanlı, E.
Format: Article
Language:English
Subjects:
Anesthetics, Combined
Colonoscopy - methods
Double-Blind Method
Family Medicine
Female
General Practice
Heart Rate - drug effects
Humans
Hypertension - chemically induced
Hypnotics and Sedatives
Hypotension - chemically induced
Internal Medicine
Ketamine
Male
Medicine
Medicine & Public Health
Middle Aged
Monitoring, Physiologic
Original Article
Postoperative Nausea and Vomiting - chemically induced
Propofol
Prospective Studies
Respiratory Insufficiency - chemically induced
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Summary:Background and aims In this study, we compared duration for reaching desired Ramsay Sedation Score (RSS) and postoperative recovery according to Modified Aldrete Score (MAS) of propofol and propofol-ketamine combination in a group of colonoscopy patients. Rates of cardiovascular, respiratory, laryngospasm, visual and nausea/vomiting complications were also compared as secondary outcomes. Methods This is a double-blinded prospective randomized controlled trial. 95 patients were included and blocked randomized to either propofol (GroupP, n : 47) or propofol-ketamine (GroupPK, n : 48). GroupP patients received 0.5 mg/kg propofol and GroupPK received 0.5 mg/kg ketamine-propofol. Subjects were monitorized noninvasively preoperatively and every 5 min during procedure. RSS was recorded for every minute before starting procedure and for every 5 min during procedure. Recovery after colonoscopy was evaluated according to MAS. Same observer checked for MAS just after procedure in postoperative 1 min and for every 3 min during follow-up. Postoperative respiratory depression was defined as rate 50 mmHg or SO 2
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-015-1348-8