Genome-Wide Gene–Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-08, Vol.68 (2), p.348-355
• Main Authors: Li, Changwei, He, Jiang, Chen, Jing, Zhao, Jinying, Gu, Dongfeng, Hixson, James E, Rao, Dabeeru C, Jaquish, Cashell E, Gu, Charles C, Chen, Jichun, Huang, Jianfeng, Chen, Shufeng, Kelly, Tanika N
• Format: Article
• Language: English
• Subjects: ADP-Ribosylation Factors - genetics; Adult; Blood Pressure - physiology; Blood Pressure Determination - methods; Calcium-Binding Proteins - genetics; Caspases, Initiator - genetics; China - epidemiology; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Hypertension - epidemiology; Hypertension - genetics; Hypertension - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Male; Middle Aged; Molecular Chaperones - genetics; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases - genetics; Sodium Chloride - metabolism; Sodium Chloride - pharmacology
• ISSN: 0194-911X; 1524-4563; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.115.06765

We performed genome-wide analyses to identify genomic loci that interact with sodium to influence blood pressure (BP) using single-marker–based (1 and 2 df joint tests) and gene-based tests among 1876 Chinese participants of the Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study. Among GenSalt participants, the average of 3 urine samples was used to estimate sodium excretion. Nine BP measurements were taken using a random zero sphygmomanometer. A total of 2.05 million single-nucleotide polymorphisms were imputed using Affymetrix 6.0 genotype data and the Chinese Han of Beijing and Japanese of Tokyo HapMap reference panel. Promising findings (P