Role of Preferential Ions of Ammonium Ionic Liquid in Destabilization of Collagen

Ions play a key role in the destabilization of collagen. This study explores the effect of diethyl methyl ammonium methane sulfonate (AMS), an ionic liquid (IL), on different hierarchical orderings of collagen, namely, at the molecular and fibrillar levels. The rheological behavior and secondary str...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2016-07, Vol.120 (27), p.6515-6524
Main Authors: Tarannum, Aafiya, Muvva, Charuvaka, Mehta, Ami, Raghava Rao, J, Fathima, N. Nishad
Format: Article
Language:English
Subjects:
Animals
Circular Dichroism
Collagen Type I - chemistry
Collagen Type I - metabolism
Hydrogen Bonding
Ionic Liquids - chemistry
Ions - chemistry
Mesylates - chemistry
Molecular Dynamics Simulation
Protein Stability
Protein Structure, Secondary
Rats
Rheology
Spectroscopy, Fourier Transform Infrared
Tendons - metabolism
Thermodynamics
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Summary:Ions play a key role in the destabilization of collagen. This study explores the effect of diethyl methyl ammonium methane sulfonate (AMS), an ionic liquid (IL), on different hierarchical orderings of collagen, namely, at the molecular and fibrillar levels. The rheological behavior and secondary structural changes reveal changes in the hydrogen-bonding environment of collagen, leading to alterations in the triple helical structure of collagen. An increase in the concentration of AMS resulted in swelling of rat-tail tendon fibers, and also, decreased thermal stability signifies that ions are obliged to destabilize collagen at the fibrillar level. Molecular modeling studies confirm that anions are judiciously held responsible for structural deformities in collagen, whereas cations have a tenuous effect. Thus, the preferential role of ions present in an ammonium IL has been elucidated in this study.
ISSN:1520-6106
1520-5207
DOI:10.1021/acs.jpcb.6b02723