Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C–H Amidation Reaction

The first Rh-catalyzed C–H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow...

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Bibliographic Details
Published in:Organic letters 2016-07, Vol.18 (14), p.3434-3437
Main Authors: Maiden, Tracy M. M, Swanson, Stephen, Procopiou, Panayiotis A, Harrity, Joseph P. A
Format: Article
Language:English
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Summary:The first Rh-catalyzed C–H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01612