(1)H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients

The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2016-05, Vol.468 (1), p.168-172
Main Authors: Menschikov, P E, Semenova, N A, Ublinskiy, M V, Akhadov, T A, Keshishyan, R A, Lebedeva, I S, Omelchenko, M A, Kaleda, V G, Varfolomeev, S D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Creatine - metabolism
Frontal Lobe - diagnostic imaging
Frontal Lobe - metabolism
Functional Laterality
gamma-Aminobutyric Acid - metabolism
Glutamic Acid - metabolism
Glutamine - metabolism
Humans
Male
Prodromal Symptoms
Proton Magnetic Resonance Spectroscopy - methods
Risk
Schizophrenia - diagnostic imaging
Schizophrenia - metabolism
Young Adult
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Summary:The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.
ISSN:1608-3091
DOI:10.1134/S1607672916030029