Effect of Hepatitis C Virus Coinfection on the Content of CD4+ and CD8+ T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy

We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4 + T cells and an increase in the count of central CD8 + memory T cells i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-06, Vol.161 (2), p.281-283
Main Authors: Korolevskaya, L. B., Shmagel, K. V., Saidakova, E. V., Shmagel, N. G., Slobodchikova, S. V., Chereshnev, V. A.
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - virology
Cell Biology
Coinfection - drug therapy
Coinfection - immunology
Coinfection - virology
Female
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - immunology
Hepatitis C, Chronic - virology
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
Humans
Interferons - pharmacology
Interferons - therapeutic use
Internal Medicine
Laboratory Medicine
Male
Pathology
Thymus Gland - immunology
Thymus Gland - pathology
Virology
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Summary:We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4 + T cells and an increase in the count of central CD8 + memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4 + memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3395-1