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Comparative Evaluation of β-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules

We compared the results of gene molecular and immunocytochemical studies of β-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/β-catenin...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-06, Vol.161 (2), p.288-291
Main Authors: Isaeva, A. V., Zima, A. P., Saprina, T. V., Kasoyan, K. T., Popov, O. S., Brynova, O. V., Berezkina, I. S., Vasil’eva, O. A., Ryazantseva, N. V., Shabalova, I. P., Litvinova, L. S., Pak, Yu. D., Novitskii, V. V.
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Language:English
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Summary:We compared the results of gene molecular and immunocytochemical studies of β-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/β-catenin complex leading to switching from adhesion function of β-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin–β-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3397-z