Kinetics of orally administered di(2-ethylhexyl) phthalate and its metabolite, mono(2-ethylhexyl) phthalate, in male pigs

Di(2-ethylhexyl) phthalate (DEHP) is used as a plastic softener in the polymer industry and is widespread in medical devices. DEHP has been incriminated as an endocrine-disrupting chemical, and the effects of DEHP in various species have included disturbances in the reproductive system. The effects...

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Bibliographic Details
Published in:Archives of toxicology 2004-07, Vol.78 (7), p.384-389
Main Authors: LJUNGVALL, Karl, TIENPONT, Bart, DAVID, Frank, MAGNUSSON, Ulf, TÖRNEKE, Karolina
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biological and medical sciences
Castration
Diethylhexyl Phthalate - analogs & derivatives
Diethylhexyl Phthalate - blood
Diethylhexyl Phthalate - metabolism
Diethylhexyl Phthalate - pharmacokinetics
Half-Life
Hogs
Intestinal Absorption
Male
Medical sciences
Reproductive system
Swine
Time Factors
Tissue Distribution
Toxicology
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Summary:Di(2-ethylhexyl) phthalate (DEHP) is used as a plastic softener in the polymer industry and is widespread in medical devices. DEHP has been incriminated as an endocrine-disrupting chemical, and the effects of DEHP in various species have included disturbances in the reproductive system. The effects of the chemical have varied, depending upon exposure routes and species. This study was performed in order to characterise the kinetics of DEHP and its metabolite mono(2-ethylhexyl) phthalate (MEHP) in the young male pig, an omnivore model-species for research in reproductive toxicology. Eight pigs were given 1000 mg DEHP/kg bodyweight by oral gavage. The concentrations of DEHP and MEHP were then measured in the plasma and tissues of the pigs at different time points after administration. There was no consistent rise above contamination levels of concentrations of DEHP in the plasma of the pigs. However, the metabolite MEHP reached the systemic blood circulation. The half-life of MEHP in the systemic blood circulation was calculated to be 6.3 h. Absorption from the intestine was biphasic in six of the eight pigs and the mono-exponential elimination-phase started 16 h after the after the administration of DEHP. To conclude, MEHP consistently reaches the systemic circulation in the pig when DEHP is administered orally. The kinetic pattern of the parent substance on the other hand is more difficult to characterise.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-004-0558-z