Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne human viral disease with fatality rate up to 30%. Two genetic lineages of CCHF virus (CCHFV) are present in Europe - lineage Europe 1 which contains pathogenic CCHFV strains, and lineage Europe 2 consisting of AP92 and AP92-like strains. In orde...

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Bibliographic Details
Published in:Ticks and tick-borne diseases 2016-07, Vol.7 (5), p.1024-1028
Main Authors: Panayotova, Elitsa, Papa, Anna, Trifonova, Iva, Christova, Iva
Format: Article
Language:English
Subjects:
Animals
Bulgaria - epidemiology
Cattle - parasitology
Europe
Goats - parasitology
Hemorrhagic Fever Virus, Crimean-Congo - classification
Hemorrhagic Fever Virus, Crimean-Congo - genetics
Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification
Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity
Humans
Ixodidae - virology
Phylogeny
Sheep - parasitology
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Summary:Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne human viral disease with fatality rate up to 30%. Two genetic lineages of CCHF virus (CCHFV) are present in Europe - lineage Europe 1 which contains pathogenic CCHFV strains, and lineage Europe 2 consisting of AP92 and AP92-like strains. In order to investigate CCHFV distribution and potential risk for humans, ticks were collected from livestock in the five districts where CCHF cases have been reported in the last five years in Bulgaria. CCHFV lineage Europe 1 was detected in 39 of 623 Hyalomma marginatum ticks (6.3%; range per village 2.7-15.2%), while CCHFV lineage Europe 2 was detected for the first time in Bulgaria in 49 of 415 Rhipicephalus sanguineus sensu lato ticks (11.8%; range 0-58.3%). The present study shows that both Europe 1 and Europe 2 CCHFV lineages are present in Bulgaria. The pathogenic role of the AP92-like strains remains to be elucidated.
ISSN:1877-959X
1877-9603
DOI:10.1016/j.ttbdis.2016.05.010