p24 family proteins: key players in the regulation of trafficking along the secretory pathway

p24 family proteins have been known for a long time, but their functions have remained elusive. However, they are emerging as essential regulators of protein trafficking along the secretory pathway, influencing the composition, structure, and function of different organelles in the pathway, especial...

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Bibliographic Details
Published in:Protoplasma 2016-07, Vol.253 (4), p.967-985
Main Authors: Pastor-Cantizano, Noelia, Montesinos, Juan Carlos, Bernat-Silvestre, César, Marcote, María Jesús, Aniento, Fernando
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biomedical and Life Sciences
Cell Biology
Conserved Sequence
COP-Coated Vesicles - physiology
Evolution, Molecular
Humans
Life Sciences
Membrane Transport Proteins - chemistry
Membrane Transport Proteins - physiology
Organ Specificity
Plant Sciences
Protein Multimerization
Protein Processing, Post-Translational
Protein Transport
Proteolysis
Review Article
Zoology
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Summary:p24 family proteins have been known for a long time, but their functions have remained elusive. However, they are emerging as essential regulators of protein trafficking along the secretory pathway, influencing the composition, structure, and function of different organelles in the pathway, especially the ER and the Golgi apparatus. In addition, they appear to modulate the transport of specific cargos, including GPI-anchored proteins, G-protein-coupled receptors, or K/HDEL ligands. As a consequence, they have been shown to play specific roles in signaling, development, insulin secretion, and the pathogenesis of Alzheimer’s disease. The search of new putative ligands may open the way to discover new functions for this fascinating family of proteins.
ISSN:0033-183X
1615-6102
DOI:10.1007/s00709-015-0858-6