An array of individually addressable micro-needles for mapping pH distributions

This work describes the preparation of an array of individually addressable pH sensitive microneedles which are sensitized by electrodepositing iridium oxide. The impact of the deposition potential, storage conditions and interferents on the sensor characteristics such as slope, offset, intra- and i...

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Bibliographic Details
Published in:Analyst (London) 2016-08, Vol.141 (15), p.4659-4666
Main Authors: Zuliani, Claudio, Ng, Fu Siong, Alenda, Andrea, Eftekhar, Amir, Peters, Nicholas S, Toumazou, Christofer
Format: Article
Language:English
Subjects:
Arrays
Deposition
Ischemia
Mapping
Needles
Oxides
Reproducibility
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Summary:This work describes the preparation of an array of individually addressable pH sensitive microneedles which are sensitized by electrodepositing iridium oxide. The impact of the deposition potential, storage conditions and interferents on the sensor characteristics such as slope, offset, intra- and inter-batch reproducibility is investigated. The device may be a useful tool for carrying out direct pH measurements of soft and heterogeneous samples such as tissues and organs. For example, we demonstrated that the microneedle array can be employed for real-time mapping of the cardiac pH distribution during cycles of global ischemia and reperfusion. This work describes the preparation of an array of individually addressable pH sensitive microneedles which demonstrated suitable for measuring pH distribution during heart ischemia and reperfusion cycles.
ISSN:0003-2654
1364-5528
DOI:10.1039/c6an00639f