COHgb levels predict the long-term development of acute myocardial infarction in CO poisoning

There are several studies evaluating the cardiac effects of carbon monoxide (CO) poisoning during the acute period; however, the number of studies evaluating the long-term cardiac effects is limited. The present study aimed to evaluate the effects of blood carboxyhemoglobin (COHb) levels, elevated d...

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Bibliographic Details
Published in:The American journal of emergency medicine 2016-05, Vol.34 (5), p.840-844
Main Authors: Kaya, Hakki, Coşkun, Abuzer, Beton, Osman, Zorlu, Ali, Kurt, Recep, Yucel, Hasan, Gunes, Hakan, Yılmaz, M. Birhan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Biomarkers - blood
Carbon monoxide
Carbon Monoxide Poisoning - blood
Carbon Monoxide Poisoning - complications
Carbon Monoxide Poisoning - diagnosis
Carboxyhemoglobin - metabolism
Cardiovascular disease
Confidence intervals
Cross-Sectional Studies
Emergency medical care
Emergency medical services
Emergency Service, Hospital
Family medical history
Female
Follow-Up Studies
Glucose
Heart attacks
Hospitals
Humans
Hypertension
Laboratories
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - etiology
Poisoning
Prognosis
Proportional Hazards Models
Risk Assessment
ROC Curve
Studies
Variables
Young Adult
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Summary:There are several studies evaluating the cardiac effects of carbon monoxide (CO) poisoning during the acute period; however, the number of studies evaluating the long-term cardiac effects is limited. The present study aimed to evaluate the effects of blood carboxyhemoglobin (COHb) levels, elevated due to CO poisoning on the long-term development of acute myocardial infarction (AMI). This cross-sectional cohort study included a total of 1013 consecutive patients who presented to the emergency department (ED) due to CO poisoning, between January 2005 and December 2007. The diagnosis of CO poisoning was made according to the medical history and a COHb level of greater than 5%. In terms of AMI development, the patients were followed up for an average of 56months. At the end of follow-up, 100 (10%) of 1013 patients experienced AMI. Carboxyhemoglobin levels at the time of poisoning were higher among those who were diagnosed with AMI compared to those who were not (55%±6% vs 30%±7%; P
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2016.01.036