Adequate Margins to Prevent Local Re-recurrence of Rectal Cancer: Viewpoint of Pathological Findings

A sufficient surgical margin is critical for preventing re-recurrence and achieving R0 status after resection of a local recurrence of rectal cancer (LRRC). Re-recurrence-free survival was analyzed in 110 cases of LRRC according to histological type of primary lesion. The circumferential resection m...

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Published in:Anticancer research 2015-12, Vol.35 (12), p.6747-6754
Main Authors: Komori, Koji, Kimura, Kenya, Kinoshita, Takashi, Ito, Seiji, Abe, Tetsuya, Senda, Yoshiki, Misawa, Kazunari, Ito, Yuichi, Uemura, Norihisa, Natsume, Seiji, Kawakami, Jiro, Iwata, Yoshinori, Tsutsuyama, Masayuki, Shigeyoshi, Itaru, Akazawa, Tomoyuki, Hayashi, Daisuke, Shimizu, Yasuhiro
Format: Article
Language:English
Subjects:
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Rectal Neoplasms - pathology
Rectal Neoplasms - prevention & control
Retrospective Studies
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container_end_page 6754
container_issue 12
container_start_page 6747
container_title Anticancer research
container_volume 35
creator Komori, Koji
Kimura, Kenya
Kinoshita, Takashi
Ito, Seiji
Abe, Tetsuya
Senda, Yoshiki
Misawa, Kazunari
Ito, Yuichi
Uemura, Norihisa
Natsume, Seiji
Kawakami, Jiro
Iwata, Yoshinori
Tsutsuyama, Masayuki
Shigeyoshi, Itaru
Akazawa, Tomoyuki
Hayashi, Daisuke
Shimizu, Yasuhiro
description A sufficient surgical margin is critical for preventing re-recurrence and achieving R0 status after resection of a local recurrence of rectal cancer (LRRC). Re-recurrence-free survival was analyzed in 110 cases of LRRC according to histological type of primary lesion. The circumferential resection margin (CRM) was classified as 'R1' (x=0 μm), 'R0 shortness' (0 μm
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Re-recurrence-free survival was analyzed in 110 cases of LRRC according to histological type of primary lesion. The circumferential resection margin (CRM) was classified as 'R1' (x=0 μm), 'R0 shortness' (0 μm &lt;x&lt;2,000 μm), or 'R0 longness' (x≥2,000 μm). The histological change from the primary lesion to the recurrent lesion was classified as 'No change pattern', from well- to moderately-differentiated (W/M) to an expanding lesion; as 'Change pattern', from W/M to an infiltrating lesion. Re-recurrence-free survival was better in 'R0 longness' than 'R0 shortness' groups and showed that 'No change pattern' cases had considerably better prognosis than 'Change pattern' cases. Ensuring a CRM &gt;2,000 μm during resection of LRRC is more likely to prevent re-recurrence. 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subjects Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Rectal Neoplasms - pathology
Rectal Neoplasms - prevention & control
Retrospective Studies
title Adequate Margins to Prevent Local Re-recurrence of Rectal Cancer: Viewpoint of Pathological Findings
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