Transcranial direct current stimulation (tDCS) neuromodulatory effects on mechanical hyperalgesia and cortical BDNF levels in ovariectomized rats

Epidemiological studies show that painful disorders are more prevalent in women than in men, and the transcranial direct current stimulation (tDCS) technique has been tested in chronic pain states. We explored the effect of tDCS on pain behavior and brain-derived neurotrophic factor (BDNF) levels in...

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Bibliographic Details
Published in:Life sciences (1973) 2016-01, Vol.145, p.233-239
Main Authors: da Silva Moreira, Sônia Fátima, Medeiros, Liciane Fernandes, de Souza, Andressa, de Oliveira, Carla, Scarabelot, Vanessa Leal, Fregni, Felipe, Caumo, Wolnei, Torres, Iraci L.S.
Format: Article
Language:English
Subjects:
Animals
BDNF
Brain-Derived Neurotrophic Factor - analysis
Brain-Derived Neurotrophic Factor - blood
Brain-Derived Neurotrophic Factor - metabolism
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Female
Hippocampus - metabolism
Hippocampus - pathology
Humans
Hyperalgesia - blood
Hyperalgesia - etiology
Hyperalgesia - pathology
Hyperalgesia - therapy
Male
Ovariectomy
Ovariectomy - adverse effects
Pain
Pain Measurement
Pain Threshold
Rats
Rats, Wistar
TDCS
Transcranial Direct Current Stimulation
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Summary:Epidemiological studies show that painful disorders are more prevalent in women than in men, and the transcranial direct current stimulation (tDCS) technique has been tested in chronic pain states. We explored the effect of tDCS on pain behavior and brain-derived neurotrophic factor (BDNF) levels in ovariectomized rats. Forty-five female Wistar adult rats were distributed into five groups: control (CT), ovariectomy+tDCS (OT), ovariectomy+sham tDCS (OS), sham ovariectomy+tDCS (ST), and sham ovariectomy+sham tDCS (SS). The rats were subjected to cathodal tDCS. The vaginal cytology and the estradiol levels confirmed the hormonal status. In addition, nociceptive behavior was evaluated using the tail-flick, von Frey, and hot-plate tests, as well as the BDNF levels in the serum, hypothalamus, hippocampus, spinal cord, and cerebral cortex. One-way analysis of variance (ANOVA) or two-way ANOVA was used for statistical analysis, followed by the Bonferroni, and P-value
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2015.10.011