Preparation of a novel chitosan-microcapsules/starch blend film and the study of its drug-release mechanism

•Incorporating microcapsules into starch film, a novel drug delivery system for pharmaceutical application was prepared.•With the development of synergistic interactions between these drug-carriers, the performances of the blend were improved significantly.•The blend film was found to be pH-sensitiv...

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Bibliographic Details
Published in:International journal of biological macromolecules 2016-06, Vol.87, p.114-122
Main Authors: Huo, Weiqiang, Xie, Gancheng, Zhang, Weixin, Wang, Wei, Shan, Junyang, Liu, Hechou, Zhou, Xiaohua
Format: Article
Language:English
Subjects:
Buffers
Chitosan - chemistry
Chitosan-microcapsules/starch blend film
Drug Carriers - chemistry
Drug Liberation
Drug-release mechanism
Hydrogen-Ion Concentration
Mechanical Phenomena
Ofloxacin - analogs & derivatives
Ofloxacin - chemistry
Ofloxacin - pharmacology
Permeability
Starch - chemistry
Synergistic effect
Temperature
Water - chemistry
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Summary:•Incorporating microcapsules into starch film, a novel drug delivery system for pharmaceutical application was prepared.•With the development of synergistic interactions between these drug-carriers, the performances of the blend were improved significantly.•The blend film was found to be pH-sensitivity.•The blend films were possessed a pharmacodynamic efficacy after the incorporation. A novel drug delivery system, chitosan-microcapsules/starch blend film for antofloxacin controlled release, was prepared, and characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (X-RD), thermogravimetry and derivative thermogravimetry (TG/DTG), and scanning electron microscopy (SEM). Following incorporation of the chitosan-microcapsules in the film matrix, the synergistic interactions between these drug-carriers were significant. The thermostability and mechanical properties of the blend film were greatly improved by the incorporation of the microcapsules. The water resistance of the blend film was enhanced by increasing the content of microcapsules, indicating that the microcapsules acted as moisture barriers. After being incorporated, chitosan-microcapsules/starch blend film shows a sustained drug release. The extent of the film degradation and microcapsules swelling in the release system indicated that the drug released of the blend film was pH-sensitive. The blend film exhibited pharmacodynamic efficacy because of the efficient drug releasing.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2016.02.049