Evaluation of the 5α-reductase inhibitor finasteride on reproduction and gonadal development in medaka, Oryzias latipes

Highlights • Fish were exposed to the 5-α reductase inhibitor, finasteride, over three generations. • Effects in fish are similar to those observed in higher vertebrates. • Finasteride induced testes maldevelopment, degeneration and Leydig cell hyperplasia. • Finasteride increased incidence of accel...

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Bibliographic Details
Published in:General and comparative endocrinology 2015-05, Vol.216, p.64-76
Main Authors: Lee, Michael R, Loux-Turner, Jana R, Oliveira, Kenneth
Format: Article
Language:English
Subjects:
5-alpha Reductase Inhibitors - pharmacology
Androgen receptor
Androgens - metabolism
Animals
Dihydrotestosterone - metabolism
Disorders of Sex Development
Endocrinology & Metabolism
Female
Fertility - drug effects
Finasteride - pharmacology
Freshwater
Gonads - drug effects
Gonads - growth & development
Gonads - metabolism
Intersex
Male
Multi-generation
Oryzias - physiology
Oryzias latipes
Ovarian Follicle - cytology
Ovarian Follicle - drug effects
Ovarian Follicle - metabolism
Parturition
Post-ovulatory follicle involution
Rao–Scott Cochran–Armitage by slices
Receptors, Androgen - metabolism
Reproduction - drug effects
Reproduction - physiology
Signal Transduction
Teleost
Testosterone - metabolism
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Summary:Highlights • Fish were exposed to the 5-α reductase inhibitor, finasteride, over three generations. • Effects in fish are similar to those observed in higher vertebrates. • Finasteride induced testes maldevelopment, degeneration and Leydig cell hyperplasia. • Finasteride increased incidence of accelerated post-ovulatory follicle involution. • Evidence that 5-α reductase and DHT have a role in androgen signaling in fish.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2015.04.008