Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance

Summary Objective Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations...

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Published in:Clinical endocrinology (Oxford) 2016-05, Vol.84 (5), p.756-763
Main Authors: Puig, Josep, Blasco, Gerard, Daunis-i-Estadella, Josep, Moreno, María, Molina, Xavier, Alberich-Bayarri, Angel, Xifra, Gemma, Pedraza, Salvador, Ricart, Wifredo, Fernández-Aranda, Fernando, Fernández-Real, José Manuel
Format: Article
Language:English
Subjects:
Adult
Anisotropy
Bayes Theorem
Body Mass Index
Brain - pathology
Brain - physiopathology
Cognition - physiology
Cross-Sectional Studies
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multivariate Analysis
Neuropsychological Tests
NMR
Nuclear magnetic resonance
Obesity - blood
Obesity - physiopathology
Obesity - psychology
Osteocalcin - blood
Predictive Value of Tests
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Summary:Summary Objective Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance. Design, Patients and Measurements We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI‐metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery. Results Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12954