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Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance
Summary Objective Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations...
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| Published in: | Clinical endocrinology (Oxford) 2016-05, Vol.84 (5), p.756-763 |
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| container_title | Clinical endocrinology (Oxford) |
| container_volume | 84 |
| creator | Puig, Josep Blasco, Gerard Daunis-i-Estadella, Josep Moreno, María Molina, Xavier Alberich-Bayarri, Angel Xifra, Gemma Pedraza, Salvador Ricart, Wifredo Fernández-Aranda, Fernando Fernández-Real, José Manuel |
| description | Summary
Objective
Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance.
Design, Patients and Measurements
We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI‐metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery.
Results
Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate |
| doi_str_mv | 10.1111/cen.12954 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1805512039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4009282011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4244-cd599a49aec7170d93dd14bfe773fdc11e98337f9ddca1e899dd2b28ab8a36153</originalsourceid><addsrcrecordid>eNqFkc1u1DAURi0EotPCghdAkdjAIq1_4theolEZkEYFpKKysxz7pnVJ7KmdMO3b18O0XSAhvLlenO9I934IvSH4mJR3YiEcE6p48wwtCGt5TWnLn6MFZhjXuG2bA3SY8zXGmEssXqID2ja4VUQu0O06biFVGdI8VjFPEK0ZrA-VjaFop2QmH0OuTILK5BytNxO4auunq6pLpoCjt6kE02ynOZmhslcmXEJJhILFlKGoLoOf_G-oNpD6mEZT1K_Qi94MGV4_zCP049Pp-fJzvf66-rL8uK5tQ5umto4rZRplwAoisFPMOdJ0PQjBemcJASUZE71yzhoCUpUP7ag0nTSsJZwdofd77ybFmxnypEefLQyDCRDnrInEnBOKmfo_KoTClHAuCvruL_Q6zimURXaUJLgYZaE-7KndhXKCXm-SH0260wTrXXO6nFj_aa6wbx-MczeCeyIfqyrAyR7Y-gHu_m3Sy9OzR2W9T_jS6-1TwqRfuhVMcH1xttLy24X6eU6-6xW7Bwvgs8k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778101208</pqid></control><display><type>article</type><title>Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Puig, Josep ; Blasco, Gerard ; Daunis-i-Estadella, Josep ; Moreno, María ; Molina, Xavier ; Alberich-Bayarri, Angel ; Xifra, Gemma ; Pedraza, Salvador ; Ricart, Wifredo ; Fernández-Aranda, Fernando ; Fernández-Real, José Manuel</creator><creatorcontrib>Puig, Josep ; Blasco, Gerard ; Daunis-i-Estadella, Josep ; Moreno, María ; Molina, Xavier ; Alberich-Bayarri, Angel ; Xifra, Gemma ; Pedraza, Salvador ; Ricart, Wifredo ; Fernández-Aranda, Fernando ; Fernández-Real, José Manuel</creatorcontrib><description>Summary
Objective
Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance.
Design, Patients and Measurements
We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI‐metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery.
Results
Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R2 = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score.
Conclusions
Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12954</identifier><identifier>PMID: 26406918</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Anisotropy ; Bayes Theorem ; Body Mass Index ; Brain - pathology ; Brain - physiopathology ; Cognition - physiology ; Cross-Sectional Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multivariate Analysis ; Neuropsychological Tests ; NMR ; Nuclear magnetic resonance ; Obesity - blood ; Obesity - physiopathology ; Obesity - psychology ; Osteocalcin - blood ; Predictive Value of Tests</subject><ispartof>Clinical endocrinology (Oxford), 2016-05, Vol.84 (5), p.756-763</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4244-cd599a49aec7170d93dd14bfe773fdc11e98337f9ddca1e899dd2b28ab8a36153</citedby><cites>FETCH-LOGICAL-c4244-cd599a49aec7170d93dd14bfe773fdc11e98337f9ddca1e899dd2b28ab8a36153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26406918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puig, Josep</creatorcontrib><creatorcontrib>Blasco, Gerard</creatorcontrib><creatorcontrib>Daunis-i-Estadella, Josep</creatorcontrib><creatorcontrib>Moreno, María</creatorcontrib><creatorcontrib>Molina, Xavier</creatorcontrib><creatorcontrib>Alberich-Bayarri, Angel</creatorcontrib><creatorcontrib>Xifra, Gemma</creatorcontrib><creatorcontrib>Pedraza, Salvador</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Fernández-Aranda, Fernando</creatorcontrib><creatorcontrib>Fernández-Real, José Manuel</creatorcontrib><title>Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance.
Design, Patients and Measurements
We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI‐metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery.
Results
Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R2 = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score.
Conclusions
Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance.</description><subject>Adult</subject><subject>Anisotropy</subject><subject>Bayes Theorem</subject><subject>Body Mass Index</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Cognition - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neuropsychological Tests</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Obesity - blood</subject><subject>Obesity - physiopathology</subject><subject>Obesity - psychology</subject><subject>Osteocalcin - blood</subject><subject>Predictive Value of Tests</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAURi0EotPCghdAkdjAIq1_4theolEZkEYFpKKysxz7pnVJ7KmdMO3b18O0XSAhvLlenO9I934IvSH4mJR3YiEcE6p48wwtCGt5TWnLn6MFZhjXuG2bA3SY8zXGmEssXqID2ja4VUQu0O06biFVGdI8VjFPEK0ZrA-VjaFop2QmH0OuTILK5BytNxO4auunq6pLpoCjt6kE02ynOZmhslcmXEJJhILFlKGoLoOf_G-oNpD6mEZT1K_Qi94MGV4_zCP049Pp-fJzvf66-rL8uK5tQ5umto4rZRplwAoisFPMOdJ0PQjBemcJASUZE71yzhoCUpUP7ag0nTSsJZwdofd77ybFmxnypEefLQyDCRDnrInEnBOKmfo_KoTClHAuCvruL_Q6zimURXaUJLgYZaE-7KndhXKCXm-SH0260wTrXXO6nFj_aa6wbx-MczeCeyIfqyrAyR7Y-gHu_m3Sy9OzR2W9T_jS6-1TwqRfuhVMcH1xttLy24X6eU6-6xW7Bwvgs8k</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Puig, Josep</creator><creator>Blasco, Gerard</creator><creator>Daunis-i-Estadella, Josep</creator><creator>Moreno, María</creator><creator>Molina, Xavier</creator><creator>Alberich-Bayarri, Angel</creator><creator>Xifra, Gemma</creator><creator>Pedraza, Salvador</creator><creator>Ricart, Wifredo</creator><creator>Fernández-Aranda, Fernando</creator><creator>Fernández-Real, José Manuel</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201605</creationdate><title>Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance</title><author>Puig, Josep ; Blasco, Gerard ; Daunis-i-Estadella, Josep ; Moreno, María ; Molina, Xavier ; Alberich-Bayarri, Angel ; Xifra, Gemma ; Pedraza, Salvador ; Ricart, Wifredo ; Fernández-Aranda, Fernando ; Fernández-Real, José Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4244-cd599a49aec7170d93dd14bfe773fdc11e98337f9ddca1e899dd2b28ab8a36153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Anisotropy</topic><topic>Bayes Theorem</topic><topic>Body Mass Index</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Cognition - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neuropsychological Tests</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Obesity - blood</topic><topic>Obesity - physiopathology</topic><topic>Obesity - psychology</topic><topic>Osteocalcin - blood</topic><topic>Predictive Value of Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puig, Josep</creatorcontrib><creatorcontrib>Blasco, Gerard</creatorcontrib><creatorcontrib>Daunis-i-Estadella, Josep</creatorcontrib><creatorcontrib>Moreno, María</creatorcontrib><creatorcontrib>Molina, Xavier</creatorcontrib><creatorcontrib>Alberich-Bayarri, Angel</creatorcontrib><creatorcontrib>Xifra, Gemma</creatorcontrib><creatorcontrib>Pedraza, Salvador</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Fernández-Aranda, Fernando</creatorcontrib><creatorcontrib>Fernández-Real, José Manuel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puig, Josep</au><au>Blasco, Gerard</au><au>Daunis-i-Estadella, Josep</au><au>Moreno, María</au><au>Molina, Xavier</au><au>Alberich-Bayarri, Angel</au><au>Xifra, Gemma</au><au>Pedraza, Salvador</au><au>Ricart, Wifredo</au><au>Fernández-Aranda, Fernando</au><au>Fernández-Real, José Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>84</volume><issue>5</issue><spage>756</spage><epage>763</epage><pages>756-763</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary
Objective
Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance.
Design, Patients and Measurements
We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI‐metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery.
Results
Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R2 = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score.
Conclusions
Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26406918</pmid><doi>10.1111/cen.12954</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2016-05, Vol.84 (5), p.756-763 |
| issn | 0300-0664 1365-2265 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Anisotropy Bayes Theorem Body Mass Index Brain - pathology Brain - physiopathology Cognition - physiology Cross-Sectional Studies Female Humans Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Neuropsychological Tests NMR Nuclear magnetic resonance Obesity - blood Obesity - physiopathology Obesity - psychology Osteocalcin - blood Predictive Value of Tests |
| title | Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance |
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