Biomarkers to identify and isolate senescent cells

Highlights • There is no single biomarker which can robustly identify senescent cells. • Widely used senescent cell biomarkers should be used in combination for accuracy. • Technologies like tangential flow filtration can be used to isolate senescent cells. • Other methods, like senolytic viruses, c...

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Bibliographic Details
Published in:Ageing research reviews 2016-08, Vol.29, p.1-12
Main Authors: Matjusaitis, Mantas, Chin, Greg, Sarnoski, Ethan Anders, Stolzing, Alexandra
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Atherosclerosis - genetics
Atherosclerosis - metabolism
Atherosclerosis - therapy
Biomarkers - metabolism
Cell Separation - methods
Cell Separation - trends
Cell- and Tissue-Based Therapy - methods
Cell- and Tissue-Based Therapy - trends
Cellular Senescence - physiology
Humans
Internal Medicine
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - therapy
Neurology
Phenotype
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Summary:Highlights • There is no single biomarker which can robustly identify senescent cells. • Widely used senescent cell biomarkers should be used in combination for accuracy. • Technologies like tangential flow filtration can be used to isolate senescent cells. • Other methods, like senolytic viruses, could be used to remove senescent cells.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2016.05.003