SHP2 and UGP2 are Biomarkers for Progression and Poor Prognosis of Gallbladder Cancer

Biomarkers for the diagnosis, prognosis, and targeting therapy of gallbladder cancers are not clinically available. This study demonstrated that the percentage of cases with positive SHP2 and UGP2 expression significantly correlated with the percentage of cases with positive vimentin, β-catenin, MMP...

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Bibliographic Details
Published in:Cancer investigation 2016-07, Vol.34 (6), p.255-264
Main Authors: Wang, Qunwei, Yang, Zhu-lin, Zou, Qiong, Yuan, Yuan, Li, Jinghe, Liang, Lufeng, Zeng, Guixiang, Chen, Senlin
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenosquamous carcinoma
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Disease Progression
Female
Gallbladder cancer
Gallbladder Neoplasms - diagnosis
Gallbladder Neoplasms - metabolism
Gallbladder Neoplasms - mortality
Gallbladder Neoplasms - therapy
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Metastasis
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism
SHP2
Squamous cell carcinoma
Tumor Burden
UGP2
UTP-Glucose-1-Phosphate Uridylyltransferase - metabolism
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Summary:Biomarkers for the diagnosis, prognosis, and targeting therapy of gallbladder cancers are not clinically available. This study demonstrated that the percentage of cases with positive SHP2 and UGP2 expression significantly correlated with the percentage of cases with positive vimentin, β-catenin, MMP2, MMP9, and Ki-67 expression, large tumor size, high TNM stage, lymph node metastasis, and survival in patients with adenocarcinomas and squamous cell/adenosquamous carcinomas. Positive SHP2 and UGP2 expression are independent poor-prognostic factors in both types of tumors. Our study suggested that positive SHP2 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357907.2016.1193745