ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α

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Bibliographic Details
Published in:Journal of hepatology 2016-08, Vol.65 (2), p.314-324
Main Authors: Wu, Fu-Quan, Fang, Tian, Yu, Le-Xing, Lv, Gui-Shuai, Lv, Hong-Wei, Liang, Dong, Li, Ting, Wang, Chang-Zheng, Tan, Ye-Xiong, Ding, Jin, Chen, Yao, Tang, Liang, Guo, Lin-Na, Tang, Shan-Hua, Yang, Wen, Wang, Hong-Yang
Format: Article
Language:English
Subjects:
Animals
Autophagy
Beta-2 adrenergic receptor
Carcinoma, Hepatocellular
Disease Progression
Drug Resistance, Neoplasm
Gastroenterology and Hepatology
Humans
Liver cancer
Liver Neoplasms
Mice
Mice, Nude
Niacinamide - analogs & derivatives
Phenylurea Compounds
Receptors, Adrenergic, beta-2
Signal Transduction
Sorafenib resistance
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Summary:Graphical abstract
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2016.04.019