Transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft

Highlights • Intrarenal IL-10 inhibited kidney allograft rejection. • Intrarenal IL-10 gene transduction induced prolonged IL-10 increase in kidney allograft but transient serum IL-10 increase. • Intrarenal IL-10 modulated immune response in kidney allograft.

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Bibliographic Details
Published in:Immunology letters 2016-08, Vol.176, p.105-113
Main Authors: Xie, Jingxin, Li, Xueyi, Meng, Dan, Liang, Qiujuan, Wang, Xinhong, Wang, Li, Wang, Rui, Xiang, Meng, Chen, Sifeng
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Administration, Intravenous
Allergy and Immunology
Animals
Cell Movement - drug effects
Cells, Cultured
Chronic vascular rejection
Creatinine - blood
Graft Rejection - immunology
Graft Rejection - prevention & control
Heme oxygenase-1
Immune therapy
Immunomodulation
Interleukin-10
Interleukin-10 - genetics
Interleukin-10 - immunology
Interleukin-10 - metabolism
Kidney - physiology
Kidney Transplantation
Male
Neointima - immunology
Neointima - prevention & control
Rats
Rats, Wistar
Renal Artery - metabolism
T-Lymphocytes, Regulatory - immunology
Transduction, Genetic
Transplantation, Homologous
Vaccines, DNA - immunology
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Description
Summary:Highlights • Intrarenal IL-10 inhibited kidney allograft rejection. • Intrarenal IL-10 gene transduction induced prolonged IL-10 increase in kidney allograft but transient serum IL-10 increase. • Intrarenal IL-10 modulated immune response in kidney allograft.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.06.004