Senescent endothelial cells: Potential modulators of immunosenescence and ageing

Highlights • Vasculature senescence plays an active role in promoting an inflammatory response. • Endothelial cells are important contributors to chronic low-grade inflammation. • Ageing compromises the elimination of senescent cells by the immune system. • SASP factors promote the development of a...

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Bibliographic Details
Published in:Ageing research reviews 2016-08, Vol.29, p.13-25
Main Authors: Pantsulaia, Ia, Ciszewski, Wojciech Michal, Niewiarowska, Jolanta
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Cellular Senescence - physiology
Endothelial Cells - physiology
Humans
Immunosenescence - physiology
Inflammation - genetics
Inflammation - metabolism
Internal Medicine
MicroRNAs - genetics
MicroRNAs - metabolism
Neurology
Phenotype
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Summary:Highlights • Vasculature senescence plays an active role in promoting an inflammatory response. • Endothelial cells are important contributors to chronic low-grade inflammation. • Ageing compromises the elimination of senescent cells by the immune system. • SASP factors promote the development of a senescence phenotype in normal cells. • The full recovery of immune homeostasis may be controlled with ECs.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2016.05.011