Successful treatment of postoperative multidrug-resistant Acinetobacter baumannii meningitis by tigecycline

•Post operative meningitis is a severe infection.•A. baumannii is frequently isolated in such infection.•Tigecycline is active against A. baumannii and in combination with others antibiotics is a potential treatment for nosocomial meningitis. Tigecycline is a broad-spectrum antibiotic with activity...

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Bibliographic Details
Published in:Journal of global antimicrobial resistance. 2016-06, Vol.5, p.62-63
Main Authors: Kooli, Ikbel, Brahim, Hajer Ben, Kilani, Mohamed, Gannouni, Chokri, Aouam, Abir, Toumi, Adnene, Loussaief, Chawki, Hattab, Mohamed nejib, Chakroun, Mohamed
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter Infections - drug therapy
Adult
Anti-Bacterial Agents - therapeutic use
Colistin
Drug Resistance, Multiple, Bacterial
Humans
Male
Meningitis - drug therapy
Meningitis - microbiology
Microbial Sensitivity Tests
Minocycline - analogs & derivatives
Minocycline - therapeutic use
Nosocomial meningitis
Tigecycline
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Summary:•Post operative meningitis is a severe infection.•A. baumannii is frequently isolated in such infection.•Tigecycline is active against A. baumannii and in combination with others antibiotics is a potential treatment for nosocomial meningitis. Tigecycline is a broad-spectrum antibiotic with activity against multidrug-resistant (MDR) bacteria. It has limited indications. Studies are necessary to elaborate new guidelines. Here we report a case of postoperative MDR Acinetobacter baumannii meningitis treated by tigecycline combined with colimycin for 21 days. The treatment was well tolerated with a favourable outcome. In conclusion, tigecycline was shown to be effective in a case of MDR A. baumannii meningitis.
ISSN:2213-7165
2213-7173
DOI:10.1016/j.jgar.2015.12.003