Effects of organotin compounds on pubertal male rats

Tributyltin (TBT) and triphenyltin (TPT) induce effects in male and female reproductive organs of rodents. They also cause tumors in these organs and it is theorized that they result from endocrine disruption. We studied the effects of 40 mg methyltestosterone (MTT), 0.5 or 15 mg TBT and 2, 6 or 12...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2004-10, Vol.202 (3), p.145-158
Main Authors: Grote, Konstanze, Stahlschmidt, Beate, Talsness, Chris E., Gericke, Christine, Appel, Klaus E., Chahoud, Ibrahim
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Environmental Pollutants - toxicity
Genitalia, Male - drug effects
Genitalia, Male - pathology
Genitalia, Male - physiopathology
Luteinizing Hormone - blood
Male
Medical sciences
Methyltestosterone
Methyltestosterone - toxicity
Organ Size - drug effects
Organotin Compounds - toxicity
Penis - drug effects
Penis - growth & development
Puberty
Rats
Rats, Wistar
Reproduction
Sexual Maturation - drug effects
Sexual Maturation - physiology
Testosterone - blood
Toxicity Tests
Toxicology
Trialkyltin Compounds - toxicity
Tributyltin
Triphenyltin
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Summary:Tributyltin (TBT) and triphenyltin (TPT) induce effects in male and female reproductive organs of rodents. They also cause tumors in these organs and it is theorized that they result from endocrine disruption. We studied the effects of 40 mg methyltestosterone (MTT), 0.5 or 15 mg TBT and 2, 6 or 12 mg TPT/kg bw on the male sexual development using a modification of the Rodent 20-Day Thyroid/Pubertal Male Assay. Male Wistar rats were treated per gavage for 30 days beginning at 23 days of age. A delay in the completion of preputial separation was observed after administration of MTT and 15 mg/kg TBT. Changes in weights of one or more reproductive organs were observed in all treatment groups. Testosterone concentration was decreased in the MTT, the 15 mg TBT as well as in the 6 and 12 mg TPT groups. A decrease in luteinizing hormone (LH) concentration was observed in the MTT and 15 mg TBT groups while an increase was seen after exposure to 6 mg TPT/kg bw. We conclude that peripubertal exposure to 15 mg TBT and 6 mg TPT/kg bw clearly affected male sexual development.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2004.05.003