Distribution of Virulence-Associated Genes in Vibrio mimicus Isolates from Clinical and Environmental Origins

Distribution of virulence‐associated genes in Vibrio mimicus was studied including the toxin genes ctxA, tdh, st and vmh and the genes necessary for regulation of toxin production, toxR, toxS, toxT, tcpA and tcpP. Approximately half of clinical V. mimicus isolates possessed one or more genes encodin...

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Published in:Microbiology and immunology 2004-01, Vol.48 (7), p.547-551
Main Authors: Shinoda, Sumio, Nakagawa, Tomoko, Shi, Lei, Bi, Kewei, Kanoh, Yasuko, Tomochika, Ken-ichi, Miyoshi, Shin-ichi, Shimada, Toshio
Format: Article
Language:English
Subjects:
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacterial Toxins
Cholera Toxin - genetics
Cholera Toxin - metabolism
enterotoxic factor
Environmental Microbiology
Hemolysin Proteins - genetics
Hemolysin Proteins - metabolism
Humans
Vibrio - genetics
Vibrio - isolation & purification
Vibrio - pathogenicity
Vibrio Infections - microbiology
Vibrio mimicus
Virulence
virulence-associated genes
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Summary:Distribution of virulence‐associated genes in Vibrio mimicus was studied including the toxin genes ctxA, tdh, st and vmh and the genes necessary for regulation of toxin production, toxR, toxS, toxT, tcpA and tcpP. Approximately half of clinical V. mimicus isolates possessed one or more genes encoding V. cholerae enterotoxic factors such as ctxA, tdh and st. All of the clinical and environmental isolates possessed vmh encoding V. mimicus hemolysin (VMH). The ctxA encoding cholera toxin was detected in only 2 strains, 5% of the clinical isolates. Furthermore, there were very few strains possessing tcpP and toxT needed for the expression of ctxA. These results may suggest that VMH is a more important pathogenic factor than well recognized toxins such as cholera toxin (CT) in V. mimicus infection.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2004.tb03551.x