Are Micromegakaryocytes Specific for Refractory Cytopenia of Childhood (RCC)? A study of 38 Pediatric Patients with Thrombocytopenia Unrelated to RCC

Highlights • Micromegakaryocytes are characteristic ofrefractory cytopenia of childhood (RCC). • No threshold is established for number of micromegakaryocytes for RCC. • We identified micromegakaryocytes in non-myelodysplastic syndrome/RCC cases. • Hence the need for establishing the threshold for m...

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Bibliographic Details
Published in:Leukemia research 2016-08, Vol.47, p.84-87
Main Authors: Aqil, Barina, Punia, Jyotinder N, Curry, Choladda V, Marcogliese, Andrea N, Elghetany, MTarek
Format: Article
Language:English
Subjects:
Adolescent
Bone Marrow Examination
Child
Child, Preschool
Diagnosis, Differential
Hematology, Oncology and Palliative Medicine
Humans
Infant
Integrin beta3 - analysis
Marrow fibrosis
Megakaryocytes - pathology
Micromegakaryocytes
Myelodysplastic syndrome
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - pathology
Primary Myelofibrosis
Refractory cytopenia of childhood
Reticulin - analysis
Thrombocytopenia
Thrombocytopenia - complications
Thrombocytopenia - pathology
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Summary:Highlights • Micromegakaryocytes are characteristic ofrefractory cytopenia of childhood (RCC). • No threshold is established for number of micromegakaryocytes for RCC. • We identified micromegakaryocytes in non-myelodysplastic syndrome/RCC cases. • Hence the need for establishing the threshold for micromegakaryocytes for RCC.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2016.05.015