Novel micro RNA-based therapies for the treatment of neuroblastoma

Neuroblastoma (NB) is the most common solid tumour in children and adolescents, and accounts for up to 15% of all cancer deaths in this group. It originates in the sympathetic nervous system, and its behaviour can be very aggressive and become resistant to current treatments. A review is presented,...

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Bibliographic Details
Published in:Anales de pediatría (Barcelona, Spain : 2003) Spain : 2003), 2016-08, Vol.85 (2), p.109.e1-109.e6
Main Authors: Boloix, Ariadna, París-Coderch, Laia, Soriano, Aroa, Roma, Josep, Gallego, Soledad, Sánchez de Toledo, Josep, Segura, Miguel F
Format: Article
Language:Spanish
Subjects:
Child
Epigenesis, Genetic
Humans
MicroRNAs - drug effects
Neuroblastoma - drug therapy
Neuroblastoma - genetics
Online Access:Get full text
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Summary:Neuroblastoma (NB) is the most common solid tumour in children and adolescents, and accounts for up to 15% of all cancer deaths in this group. It originates in the sympathetic nervous system, and its behaviour can be very aggressive and become resistant to current treatments. A review is presented, summarising the new alternative therapies based on epigenetics, i.e., modulators of gene expression, such as microRNAs and their potential application in the clinical practice of NB treatment.
ISSN:1695-9531
DOI:10.1016/j.anpedi.2015.07.016