Factors predicting successful discontinuation of continuous renal replacement therapy

This multicentre, retrospective observational study was conducted from January 2010 to December 2010 to determine the optimal time for discontinuing continuous renal replacement therapy (CRRT) by evaluating factors predictive of successful discontinuation in patients with acute kidney injury. Analys...

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Bibliographic Details
Published in:Anaesthesia and intensive care 2016-07, Vol.44 (4), p.453-457
Main Authors: Katayama, S., Uchino, S., Uji, M., Ohnuma, T., Namba, Y., Kawarazaki, H., Toki, N., Takeda, K., Yasuda, H., Izawa, J., Tokuhira, N., Nagata, I.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - therapy
Acute renal failure
Aged
Care
Creatinine
Creatinine - blood
Female
Humans
Logistic Models
Male
Middle Aged
Nephrology
Oliguria
Patients
Renal intensive care
Renal Replacement Therapy
Retrospective Studies
Time Factors
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Summary:This multicentre, retrospective observational study was conducted from January 2010 to December 2010 to determine the optimal time for discontinuing continuous renal replacement therapy (CRRT) by evaluating factors predictive of successful discontinuation in patients with acute kidney injury. Analysis was performed for patients after CRRT was discontinued because of renal function recovery. Patients were divided into two groups according to the success or failure of CRRT discontinuation. In multivariate logistic regression analysis, urine output at discontinuation, creatinine level and CRRT duration were found to be significant variables (area under the receiver operating characteristic curve for urine output, 0.814). In conclusion, we found that higher urine output, lower creatinine and shorter CRRT duration were significant factors to predict successful discontinuation of CRRT.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057X1604400401