Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons

Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potentia...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2016-07, Vol.138 (29), p.9049-9052
Main Authors: Lyu, Yan, Xie, Chen, Chechetka, Svetlana A, Miyako, Eijiro, Pu, Kanyi
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Infrared Rays
Light
Mice
Nanostructures - chemistry
Neurons - cytology
Neurons - drug effects
Neurons - radiation effects
Optogenetics
Polymers - chemistry
Polymers - pharmacology
Semiconductors
Temperature
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Summary:Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potential alternative approach to optogenetics using semiconducting polymer nanobioconjugates (SPNsbc) as the photothermal nanomodulator to control the thermosensitive ion channels in neurons. SPNsbc are designed to efficiently absorb the NIR light at 808 nm and have a photothermal conversion efficiency higher than that of gold nanorods. By virtue of the fast heating capability in conjunction with the precise targeting to the thermosensitive ion channel, SPNsbc can specifically and rapidly activate the intracellular Ca2+ influx of neuronal cells in a reversible and safe manner. Our study provides an organic nanoparticle based strategy that eliminates the need for genetic transfection to remotely regulate cellular machinery.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.6b05192