Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo

• Published in: Brain research 2001-07, Vol.906 (1), p.157-163
• Main Authors: Nogueira, Cristina Wayne, Rotta, Liane Nanci, Perry, Marcos Luiz, Souza, Diogo Onofre, Teixeira da Rocha, João Batista
• Format: Article
• Language: English
• Subjects: Adenylate cyclase and GMP-PNP binding protein; Animals; Benzene Derivatives - toxicity; Binding, Competitive - drug effects; Binding, Competitive - physiology; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Chemical and industrial products toxicology. Toxic occupational diseases; Diphenyl diselenide; Diphenyl ditelluride; Dithiothreitol - pharmacokinetics; Dizocilpine Maleate - pharmacokinetics; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists - pharmacokinetics; Glutamatergic system; Glutamic Acid - metabolism; Glutamic Acid - pharmacokinetics; Guanylyl Imidodiphosphate - pharmacokinetics; Male; Medical sciences; Neurotoxicity; Neurotoxins - pharmacology; Organochalcogen; organohalogens; Organometallic Compounds - toxicity; Organoselenium Compounds - toxicity; Presynaptic Terminals - drug effects; Presynaptic Terminals - metabolism; Rats; Rats, Wistar; Subcellular Fractions - drug effects; Subcellular Fractions - metabolism; Synaptic Membranes - drug effects; Synaptic Membranes - metabolism; Synaptic Transmission - drug effects; Synaptic Transmission - physiology; Tellurium - toxicity; Toxicology; Tritium - pharmacokinetics; Various organic compounds
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(01)02165-5

The aim of this study was to investigate the possible involvement of the glutamatergic system in the toxicity of organochalcogens, since this is an important neurotransmitter system for signal transduction and neural function. The results indicated that 100 μM diphenyl diselenide (PhSe) 2 and diphenyl ditelluride (PhTe) 2 inhibit by 50 and 70% ( P