Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla

• Published in: Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2001-08, Vol.22 (8), p.1331-1338
• Main Authors: Daughters, Randall S., Hofbauer, Randall D., Grossman, Aaron W., Marshall, Anne-Marie, Brown, Eric M., Hartman, Boyd K., Faris, Patricia L.
• Format: Article
• Language: English
• Subjects: 5-HT 3 receptors; Animals; Brain - metabolism; c-fos proteins; Cholecystokinin; Cholecystokinin - biosynthesis; Cholecystokinin - pharmacology; Drug Interactions; Feeding Behavior - drug effects; Food intake; Immunohistochemistry; Ligands; Male; Models, Biological; Ondansetron; Ondansetron - pharmacology; Proto-Oncogene Proteins c-fos - metabolism; Rats; Rats, Sprague-Dawley; Serotonin Antagonists - pharmacology; Vagus nerves
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/S0196-9781(01)00460-0

Serotonin 5-HT 3 antagonists have been suggested for treatment of several disorders involving altered gastrointestinal (GI) function. CCK also has well documented GI actions on both food intake and vago-vagal reflexes. To evaluate potential interactions, the effect of a 5-HT 3 antagonist, ondansetron, on exogenous CCK induced satiety and c-fos activation was determined. Ondansetron reduced both actions of CCK by approximately 50%. The reduction in c-fos was localized to a specific subregion of the dorsal medulla, suggesting that a distinct subpopulation of CCK receptive fibers are modulated by 5-HT 3 ligands. Treatments using 5-HT 3 antagonists also may affect endogenous CCK functions.