Bronchoconstriction-triggered cough in atopic cough: A retrospective study

Background: Atopic cough (AC) and cough variant asthma (CVA) were identified as major causes of chronic non-productive cough in a Japanese study. A characteristic feature of CVA is the presence of a heightened cough response to bronchoconstriction. On the other hand, the cough response to bronchocon...

Full description

Saved in:
Bibliographic Details
Published in:Experimental lung research 2016-05, Vol.42 (5), p.227-231
Main Authors: Ohkura, Noriyuki, Hara, Johsuke, Sakai, Tamami, Okazaki, Akihito, Abo, Miki, Kasahara, Kazuo, Fujimura, Masaki
Format: Article
Language:English
Subjects:
Adult
Aged
Asthma - physiopathology
atopic cough
Bronchoconstriction
Chronic Disease
Cough - etiology
cough variant asthma
Female
Humans
Male
methacholine
Methacholine Chloride
Middle Aged
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Atopic cough (AC) and cough variant asthma (CVA) were identified as major causes of chronic non-productive cough in a Japanese study. A characteristic feature of CVA is the presence of a heightened cough response to bronchoconstriction. On the other hand, the cough response to bronchoconstriction in AC remains unclear. Methods: Methacholine (Mch)-induced cough in AC was measured and compared with that in CVA. Diagnoses of AC and CVA were made based on patient history, physical examination, response to bronchodilator therapy, cough reflex sensitivity to capsaicin, spirometry, and airway responsiveness to methacholine. Results: Thirteen AC patients and 12 CVA patients in whom the criteria were met were recruited to the study. After inhalation of Mch at PC35-PEF40 that means milder bronchoconstriction than PC20-FEV1, cough was triggered a few times in AC. [cough number: 1/ 32 min (0-40)]. Conversely, significantly greater number of coughs was provoked in CVA, compared with AC [cough number: 35.5/ 32 min (25-125), p < 0.05]. Conclusions: The cough response to bronchoconstriction is reduced in AC compared to CVA. This feature may be useful in the diagnosis of chronic cough.
ISSN:0190-2148
1521-0499
DOI:10.1080/01902148.2016.1195460