The effect of chlorzoxazone on acute pain after spine surgery. A randomized, blinded trial

• Published in: Acta anaesthesiologica Scandinavica 2016-09, Vol.60 (8), p.1152-1160
• Main Authors: Nielsen, R. V., Fomsgaard, J. S., Siegel, H., Martusevicius, R., Mathiesen, O., Dahl, J. B.
• Format: Article
• Language: English
• Subjects: Acute Pain - drug therapy; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Chlorzoxazone - therapeutic use; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central - therapeutic use; Pain management; Pain, Postoperative - drug therapy; Prospective Studies; Spine - surgery; Surgery
• ISSN: 0001-5172; 1399-6576
• DOI: 10.1111/aas.12754

Background Chlorzoxazone is a muscle relaxant administered for musculoskeletal pain, and as an analgesic adjunct for post‐operative pain. Chlorzoxazone for low back pain is currently not advised due to the lack of placebo‐controlled trials. We explored the effect of chlorzoxazone on acute pain after spine surgery. Methods One hundred and ten patients were randomly assigned to 500 mg oral chlorzoxazone or placebo in this blinded study of patients having spine surgery under general anaesthesia. In the 4 h trial period analgesia consisted of IV patient‐controlled analgesia (morphine bolus 2.5 mg). Primary outcome was pain during mobilization (visual analogue scale) 2 h after the intervention. Secondary outcomes were pain at rest, opioid consumption, nausea, vomiting, sedation and dizziness. Results For pain during mobilization 2 h after intervention, there was no significant difference between groups: 51 (21) vs. 54 (25) mm in the chlorzoxazone and placebo groups, respectively, mean difference 3 mm (95% CI −8 to 10), P = 0.59. For pain during mobilization and at rest (wAUC 1–4 h), there were no significant differences between groups. There was no significant difference in total IV morphine use 0–4 h: median 10 (7–21) vs. 13 (5–19) mg in the chlorzoxazone and placebo groups, respectively, P = 0.82. We found no significant difference in adverse effects. Conclusion No analgesic effect of single‐dose chlorzoxazone was demonstrated in patients with acute pain after spine surgery. Based on these findings, chlorzoxazone cannot be recommended for immediate treatment of acute pain after such procedures.