Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies

Oxidative stress is defined as an imbalance between the pro-oxidant and antioxidant potential of cells leading to intracellular DNA damage. To clarify the oxidative stress response as a tumor marker, we investigated measurement of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels in hepatobiliary dise...

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Bibliographic Details
Published in:Anticancer research 2016-08, Vol.36 (8), p.3899-3903
Main Authors: Nanashima, Atsushi, Izumino, Hiroo, Sumida, Yorihisa, Tominaga, Tetsuro, Wakata, Kouki, Hidaka, Shigekazu, Tsuchiya, Tomoshi, Nagayasu, Takeshi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - urine
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Cholangiocarcinoma - urine
DNA Damage - genetics
Female
Gallbladder Neoplasms - pathology
Gallbladder Neoplasms - surgery
Gallbladder Neoplasms - urine
Guanine - analogs & derivatives
Guanine - urine
Humans
Lymphatic Metastasis
Male
Middle Aged
Oxidative Stress - genetics
Reactive Oxygen Species - metabolism
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Summary:Oxidative stress is defined as an imbalance between the pro-oxidant and antioxidant potential of cells leading to intracellular DNA damage. To clarify the oxidative stress response as a tumor marker, we investigated measurement of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels in hepatobiliary diseases. Relationships between urinary 8-OHdG levels and clinicopathological factors were analyzed in 101 patients, including 84 with hepatobiliary malignancies, and 18 healthy volunteers. Co-existing biliary inflammation was detected in 8 patients. Urinary 8-OHdG levels did not correlate with any clinical or liver functional parameters. The existence of inflammation and any tumor-related factor did not correlate with urinary 8-OHdG levels either. Urinary 8-OHdG levels were significantly higher in patients with benign and malignant diseases than in healthy volunteers (p
ISSN:1791-7530