Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome

To investigate serum levels of endostatin in a well characterised cohort of patients with primary Sjögren's syndrome (pSS) and healthy controls (HC) and assess associations between these mediators and clinical parameters. All patients (n=144) were recruited from the Norwegian systemic connectiv...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2016-07, Vol.34 (4), p.690-693
Main Authors: Palm, Øyvind, Ueland, Thor, Garen, Torhild, Michelsen, Annika E, Reiseter, Silje, Aukrust, Pål, Aaløkken, Trond Mogens, Molberg, Øyvind
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Case-Control Studies
Endostatins - blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lung Diseases, Interstitial - blood
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - immunology
Male
Middle Aged
Norway
Registries
Sjogren's Syndrome - blood
Sjogren's Syndrome - diagnosis
Sjogren's Syndrome - immunology
Tomography, X-Ray Computed
Up-Regulation
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Summary:To investigate serum levels of endostatin in a well characterised cohort of patients with primary Sjögren's syndrome (pSS) and healthy controls (HC) and assess associations between these mediators and clinical parameters. All patients (n=144) were recruited from the Norwegian systemic connective tissue disease and vasculitis registry (NOSVAR) and fulfilled American-European classification criteria for pSS. Pulmonary involvement was based on clinical symptoms and abnormal findings on high-resolution computed tomography of the lungs. The controls were 100 healthy blood donors. Serum levels of endostatin was determined by enzyme immunoassay. We found higher mean levels of serum endostatin in patients with pSS compared with the controls (p
ISSN:0392-856X