Tumour markers in rheumatoid arthritis-associated interstitial lung disease

Interstitial lung disease (ILD) is the most common pulmonary extra-articular manifestations of rheumatoid arthritis (RA), but the pathogenesis of RA-ILD is unknown. The purpose of this study was to investigate the tumour markers levels in patients of rheumatoid arthritis-associated interstitial lung...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2016-07, Vol.34 (4), p.587-591
Main Authors: Wang, Ting, Zheng, Xing-Ju, Ji, Yu-Lin, Liang, Zong-An, Liang, Bin-Miao
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Area Under Curve
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - diagnosis
Biomarkers, Tumor - blood
CA-125 Antigen - blood
CA-19-9 Antigen - blood
Carcinoembryonic Antigen - blood
Chi-Square Distribution
Female
Humans
Logistic Models
Lung Diseases, Interstitial - blood
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - etiology
Male
Middle Aged
Mucin-1 - blood
Odds Ratio
Predictive Value of Tests
Retrospective Studies
Risk Factors
ROC Curve
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Summary:Interstitial lung disease (ILD) is the most common pulmonary extra-articular manifestations of rheumatoid arthritis (RA), but the pathogenesis of RA-ILD is unknown. The purpose of this study was to investigate the tumour markers levels in patients of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and to explore the diagnostic value of serum tumour markers for RA-ILD. Twenty-eight patients with RA-ILD and 83 patients with RA only were included. Serum levels of tumour markers carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 15-3, CA125, and CA19-9 were measured. Tumour markers CA15-3, CA125 and CA19-9 were increased in RA-ILD patients compared with RA without ILD patients. Logistic regression analysis revealed that older age (OR=1.06, 95% CI=[1.02-1.11]) and higher CA125 (OR=1.03, 95% CI=[1.01-1.05]) related to the increased risk of RA-ILD. ROC curve analysis showed the relationship between CA125 and RA-ILD was moderate (area under ROC curve (AUC)=0.78, 95% CI=[0.68-0.88]). In addition, CA125 levels above the normal reference (
ISSN:0392-856X