Enzymatic Resistance of Medicinal Film Coatings Based on Chitosan

The resistance of film coatings based on chitosan and aminoglycoside antibiotics, such as amikacin sulfate, to hyaluronidase enzyme preparation is considered. Despite the use of a solid film sample in enzymatic hydrolysis, the regularities of the process are similar to those observed in the hydrolys...

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Bibliographic Details
Published in:Protection of metals and physical chemistry of surfaces 2016-03, Vol.52 (2), p.297-301
Main Authors: Tuktarova, I. F., Chernova, V. V., Lazdin, R. Yu, Kulish, E. I.
Format: Article
Language:English
Subjects:
Antibiotics
Characterization and Evaluation of Materials
Chemistry and Materials Science
Chitosan
Coatings
Corrosion and Coatings
Enzymes
Hydrolysis
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Materials Science
Metallic Materials
New Materials and Coatings in Biology and Medicine
Physical chemistry
Regularity
Sulfates
Tribology
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Summary:The resistance of film coatings based on chitosan and aminoglycoside antibiotics, such as amikacin sulfate, to hyaluronidase enzyme preparation is considered. Despite the use of a solid film sample in enzymatic hydrolysis, the regularities of the process are similar to those observed in the hydrolysis of chitosan in solution at low concentrations of substrate. The addition of the drug leads to a reduction of the rate of enzymatic hydrolysis of chitosan and provides the potentially longer service life of protective film materials on the wound surface.
ISSN:2070-2051
2070-206X
DOI:10.1134/S2070205116020313