Small molecule detection by lateral flow strips viaaptamer-gated silica nanoprobes

A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of conc...

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Bibliographic Details
Published in:Analyst (London) 2016-04, Vol.141 (8), p.2595-2599
Main Authors: Oezalp, VCengiz, Cam, Dilek, Hernandez, Frank J, Hernandez, Luiza I, Schaefer, Thomas, Oektem, Hueseyin A
Format: Article
Language:English
Subjects:
Amplification
Detection
Nanoparticles
Nanostructure
Platforms
Recognition
Silicon dioxide
Strategy
Online Access:Get full text
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Summary:A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.
ISSN:0003-2654
1364-5528
DOI:10.1039/c6an00273k