The Antiarrhythmic Effect of 4-Methyl-2,6-Diisobornylphenol in Myocardial Ischemia/Reperfusion

We studied the antiarrhythmic activity of novel sterically hindered phenols – 4-methyl-2,6- diisobornylphenol (dibornol) in acute myocardial ischemia/reperfusion in male Wistar rats. Left coronary artery occlusion (10 min) in control group induced different ventricular arrhythmia and 23% mortality o...

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Bibliographic Details
Published in:Key Engineering Materials 2016-02, Vol.683, p.469-474
Main Authors: Chernysheva, Galina, Chukicheva, Irina, Plotnikov, Mark, Smol'yakova, Vera, Shchetinin, Pyotr P., Plotnikova, Tatyana, Kuchin, Aleksandr
Format: Article
Language:English
Subjects:
Arrhythmia
Arteries
Ischemia
Males
Mortality
Occlusion
Phenols
Rats
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Summary:We studied the antiarrhythmic activity of novel sterically hindered phenols – 4-methyl-2,6- diisobornylphenol (dibornol) in acute myocardial ischemia/reperfusion in male Wistar rats. Left coronary artery occlusion (10 min) in control group induced different ventricular arrhythmia and 23% mortality of animals. Dibornol (p.o. administration 100 mg/kg 24 and 3 hours before ischemia) did not change the frequency and kinds of arrhythmia in acute ischemia, but significantly reduced the frequency and the level of seriousness of arrhythmia in the reperfusion period, decreased the mortality of rats due to lethal arrhythmia.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.683.469