The Potential Use of Natural Rubber in Pharmaceutical Closures

Current manufacturing techniques could produce natural rubber closures that meet all criteria standardized by pharmacopeias except the ultraviolet absorbance limit in the range of 220–360 nm for the closures’ leachate. The type and the dosage of the rubber compounds’ ingredients affected the ultravi...

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Bibliographic Details
Published in:Progress in rubber, plastics and recycling technology plastics and recycling technology, 2016-05, Vol.32 (2), p.87-98
Main Authors: Bich, Nguyen Ngoc, Trang, Nguyen Thi Hue, Luan, Nguyen Duy, Van Son, Huynh
Format: Article
Language:English
Subjects:
Absorbance
Antioxidants
Closures
Drugs
Innovations
Latex
Leachates
Manufacturers
Natural rubber
Pharmaceutical industry
Pharmaceuticals
Proteins
Rubber
Ultraviolet
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Summary:Current manufacturing techniques could produce natural rubber closures that meet all criteria standardized by pharmacopeias except the ultraviolet absorbance limit in the range of 220–360 nm for the closures’ leachate. The type and the dosage of the rubber compounds’ ingredients affected the ultraviolet absorbance of the leachate, while rinsing the closures in water with ultrasonic waves and ozone did not. Intensive washing of the rubber coagulum and deproteinization of the rubber latex using bromelain reduced ultraviolet absorbance of the leachate significantly. Further purification of natural rubber latex is necessary to enable the use of natural rubber in pharmaceutical closures.
ISSN:1477-7606
1478-2413
DOI:10.1177/147776061603200203