Organ Dose Estimates for Hyperthyroid Patients Treated with super( 131)I: An Update of the Thyrotoxicosis Follow-Up Study

The Thyrotoxicosis Therapy Follow-up Study (TTFUS) is comprised of 35,593 hyperthyroid patients treated from the mid-1940s through the mid-1960s. One objective of the TTFUS was to evaluate the long-term effects of high-dose iodine-131 ( super( 131)I) treatment. In the TTFUS cohort, 23,020 patients w...

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Bibliographic Details
Published in:Radiation research 2015-12, Vol.184 (6), p.595-595
Main Authors: Melo, Dunstana R, Brill, Aaron B, Zanzonico, Pat, Vicini, Paolo, Moroz, Brian, Kwon, Deukwoo, Lamart, Stephanie, Brenner, Alina, Bouville, Andre, Simon, Steven L
Format: Article
Language:English
Subjects:
Estimates
Health
Organs
Patients
Risk
Standard deviation
Thyroid gland
Toxicology
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Summary:The Thyrotoxicosis Therapy Follow-up Study (TTFUS) is comprised of 35,593 hyperthyroid patients treated from the mid-1940s through the mid-1960s. One objective of the TTFUS was to evaluate the long-term effects of high-dose iodine-131 ( super( 131)I) treatment. In the TTFUS cohort, 23,020 patients were treated with super( 131)I, including 21,536 patients with Graves disease (GD), 1,203 patients with toxic nodular goiter (TNG) and 281 patients with unknown disease. The study population constituted the largest group of hyperthyroid patients ever examined in a single health risk study. The average number ( plus or minus 1 standard deviation) of super( 131)I treatments per patient was 1.7 plus or minus 1.4 for the GD patients and 2.1 plus or minus 2.1 for the TNG patients. In this article, a biokinetic model for iodine was developed to derive organ residence times and to reconstruct the radiation-absorbed doses to the thyroid gland and to other organs resulting from administration of super( 131)I to hyperthyroid patients.
ISSN:0033-7587
1938-5404
DOI:10.1667/RR14160.1